Imaging mass spectrometry: Towards clinical diagnostics

MALDI TOF imaging mass spectrometry in clinical pathology: a valuable tool for cancer diagnostics (review).

Matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) imaging mass spectrometry (IMS) is an evolving technique in cancer diagnostics and combines the advantages of mass spectrometry (proteomics), detection of numerous molecules, and spatial resolution in histological tissue sections and cytological preparations. This method allows the detection of proteins, peptides, lipids, ...

Imaging with mass spectrometry.

[Imaging mass spectrometry].

Matrix-assisted laser desorption/ionization (MALDI)-imaging mass spectrometry (IMS) enables the visualization of the distribution of a range of biomolecules that have varied structures in the cells and tissue sections. This emerging imaging technique was initially developed as a tool for protein imaging, but recently it is increasingly being used for the imaging of small organic molecules. IMS ...

Developing mass spectrometry towards applications in clinical proteomics

Proteome versus proteins Each organism contains a single genome in virtually all its cells and thus the difference between the numerous cell types within the same organisms are attributed mainly to genetic imprinting, epigenetics, transcriptional and post-transcriptional processes. Thus studying all the protein molecules present in the living system (termed proteomics) at any given time and phy...

A mass spectrometry primer for mass spectrometry imaging.

Mass spectrometry imaging (MSI), a rapidly growing subfield of chemical imaging, employs mass spectrometry (MS) technologies to create single- and multi-dimensional localization maps for a variety of atoms and molecules. Complimentary to other imaging approaches, MSI provides high chemical specificity and broad analyte coverage. This powerful analytical toolset is capable of measuring the distr...